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. 2019 Dec 21;118(3):765–780. doi: 10.1016/j.bpj.2019.12.016

Figure 5.

Figure 5

Identifying key residues for Kv1.2 voltage-sensor function. (A) A cartoon representation of the Kv1.2 voltage sensor is given. The four membrane segments S1–S4 and the surface S4–S5 helix are shown. S4 positive charges are represented as blue sticks. (B) Per-residue importance obtained using RF classifiers and averaged over the five states of the Kv1.2 VSD is shown. The colored rectangles denote the helical segments. S4 charges (R1, R2, R3, R4, K5 and R6) are marked with the blue dashed lines. The average importance and its standard deviation are shown as the black line and the shadow around it, respectively. (C) Per-state per-residue importance is shown. The top-ranked residues are shown as sticks. The area of the hydrophobic plug is marked as a red dashed zone. To see this figure in color, go online.