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. 2020 Jan 17;21(3):1421–1430. doi: 10.3892/mmr.2020.10950

Table I.

Inflammatory mediators secreted by various types of cells in the skin.

Cell type Inflammatory factors
Mononuclear macrophages INF-γ, TNF, IL-1, GM-CSF, IL-6, IL-8, IL-12, IL-18, IL-10
Neutrophils IL-1β, TNF, IL-6, IL-8, IL-15, IFN-γ
Th1 cells IFN-γ, TNF, IL-2, IL-3, GM-CSF
Th2 cells IL-4, IL-5, IL-6, IL-10, IL-13, IL-3, GM-CSF
Th17 cells IL-17, IL-6, IL-21, IL-22, TNF-α
Mast cells TNF, IL-1, IL-4, IL-6, IL-8, IL-10, IL-13, IFN-γ
Dendritic cells IL-2, IL-4, IL-5, IL-12, INF-γ
Keratinocytes IL-18, TNF, IL-1, GM-CSF, INF-γ, IL-33
Melanocytes INF-β, IL-1, IL-8, IL-10, TNF-α
Fibroblasts IL-33, TNF, IL-6, IL-8

Th1, T helper 1; IFN-γ, interferon-γ; TNF, tumor necrosis factor; IL, interleukin; GM-CSF, granulocyte-macrophage colony stimulating factor.