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. Author manuscript; available in PMC: 2020 Apr 17.
Published in final edited form as: ACS Chem Neurosci. 2018 Oct 9;10(4):1941–1949. doi: 10.1021/acschemneuro.8b00251

Figure 6. Effect of caffeine (100 mg/kg, i.p.) on adenosine and oxygen changes during I/R injury.

Figure 6.

(A) Example adenosine and oxygen changes during normoxia, where four adenosine and two oxygen events (starred) were observed. (B) Example adenosine and oxygen changes during I/R injury with caffeine treatment, where two adenosine and one oxygen events were observed. (C) Number of adenosine event release traces during every 6 min during normoxia and I/R injury. Inset: Average number of adenosine release events decreased during caffeine+I/R (paired t-test, n = 6 animals, *p = 0.022). (D) Number of oxygen events in 6 min bins. Inset: Average number of oxygen events decreased during caffeine+ I/R injury (paired t-test, n = 6 animals, *p = <0.01). (E) For adenosine, underlying distributions of inter-event times were significantly different between normoxia and caffeine + I/R injury (KS test, n = 6 animals, ****p < 0.0001). (F) For oxygen, the distributions of inter-event times were significantly different for caffeine+I/R (KS test, n = 6 animals, ****p < 0.0001). (G) Average event concentration of adenosine events was not significantly different (paired t-test, n = 6 animals, all ADO: p = 0.75 and ADO w/O2: p =0.56). (H) Average oxygen events concentration was not significantly (paired t-test, n = 6 animals, p = 0.96).