Table 6. Statistically Significant BMI PheWAS SNPs including DM2 as a comorbidity.
Phenotype | Description | SNP | Gene | β | (SE) | Odds Ratio | PheWAS p-value | N | Cases | Controls |
---|---|---|---|---|---|---|---|---|---|---|
250.2 | Type 2 Diabetes | rs2246606 | TDH | -0.331 | 0.073 | 0.718 | 6.32x10-6 | 5566 | 459 | 5107 |
796 | Elevated prostate specific antigen [PSA] | rs9937053 | FTO | 0.882 | 0.197 | 2.416 | 7.76x10-6 | 6293 | 71 | 6222 |
796 | Elevated prostate specific antigen [PSA] | rs9930333 | FTO | 0.881 | 0.197 | 2.413 | 7.88x10-6 | 6297 | 71 | 6226 |
796 | Elevated prostate specific antigen [PSA] | rs9940128 | FTO | 0.875 | 0.197 | 2.398 | 8.66x10-6 | 6297 | 71 | 6226 |
796 | Elevated prostate specific antigen [PSA] | rs1121980 | FTO | 0.872 | 0.197 | 2.391 | 9.60x10-6 | 6298 | 71 | 6227 |
250 | Diabetes Mellitus | rs2246606 | TDH | -0.318 | 0.072 | 0.728 | 1.14x10-5 | 5577 | 470 | 5107 |
796 | Elevated prostate specific antigen [PSA] | rs1421085 | FTO | 0.855 | 0.197 | 2.351 | 1.41x10-5 | 6298 | 71 | 6227 |
796 | Elevated prostate specific antigen [PSA] | rs1558902 | FTO | 0.854 | 0.197 | 2.350 | 1.43x10-5 | 6298 | 71 | 6227 |
278.1 | Obesity | rs2948300 | N/A | 0.199 | 0.047 | 1.221 | 1.90x10-5 | 5805 | 1172 | 4633 |
796 | Elevated prostate specific antigen [PSA] | rs17817449 | FTO | 0.823 | 0.196 | 2.277 | 2.75x10-5 | 6298 | 71 | 6227 |
796 | Elevated prostate specific antigen [PSA] | rs8043757 | FTO | 0.822 | 0.196 | 2.275 | 2.82x10-5 | 6298 | 71 | 6227 |
250.2 | Type 2 Diabetes | rs2572386 | FAM167A | -0.303 | 0.073 | 0.739 | 3.57x10-5 | 5564 | 459 | 5105 |
278 | Obesity, Overweight | rs2948300 | N/A | 0.182 | 0.044 | 1.200 | 3.71x10-5 | 5980 | 1347 | 4633 |
796 | Elevated prostate specific antigen [PSA] | rs8050136 | FTO | 0.788 | 0.195 | 2.198 | 5.55x10-5 | 6298 | 71 | 6227 |
796 | Elevated prostate specific antigen [PSA] | rs9939609 | FTO | 0.787 | 0.196 | 2.197 | 5.71x10-5 | 6298 | 71 | 6227 |
250.2 | Type 2 Diabetes | rs1435277 | N/A | -0.292 | 0.073 | 0.747 | 5.94x10-5 | 5554 | 458 | 5096 |
401 | Hypertension | rs12412241 | N/A | -0.221 | 0.055 | 0.802 | 6.49x10-5 | 6057 | 1385 | 4672 |
796 | Elevated prostate specific antigen [PSA] | rs3751812 | FTO | 0.772 | 0.195 | 2.163 | 7.87x10-5 | 6297 | 71 | 6226 |
250 | Diabetes Mellitus | rs2572386 | FAM167 | -0.284 | 0.072 | 0.753 | 8.44x10-5 | 5575 | 470 | 5105 |
401.1 | Essential Hypertension | rs12412241 | N/A | -0.216 | 0.056 | 0.806 | 1.02x10-4 | 6037 | 1365 | 4672 |