Table 7. Statistically Significant Obesity PheWAS SNPs.
Phenotype | Description | SNP | Gene | β | (SE) | Odds Ratio | PheWAS p-value | N | Cases | Controls |
---|---|---|---|---|---|---|---|---|---|---|
278 | Overweight, Obesity | rs1620977 | NEGR1 | 0.409 | 0.070 | 1.506 | 4.09x10-9 | 2819 | 640 | 2179 |
278.1 | Obesity | rs1620977 | NEGR1 | 0.405 | 0.071 | 1.499 | 1.45x10-8 | 2779 | 600 | 2179 |
278.11 | Morbid Obesity | rs1620977 | NEGR1 | 0.432 | 0.080 | 1.541 | 5.96x10-8 | 2624 | 445 | 2179 |
278.1 | Obesity | rs1776012 | NEGR1 | -0.326 | 0.067 | 0.722 | 1.18x10-6 | 2762 | 594 | 2168 |
278.1 | Obesity | rs1870676 | NEGR1 | -0.324 | 0.067 | 0.723 | 1.40x10-6 | 2757 | 593 | 2164 |
278.1 | Obesity | rs9424977 | NEGR1 | -0.321 | 0.067 | 0.725 | 1.46x10-6 | 2776 | 599 | 2177 |
278 | Overweight, Obesity | rs1776012 | NEGR1 | -0.308 | 0.065 | 0.735 | 2.23x10-6 | 2802 | 634 | 2168 |
278 | Overweight, Obesity | rs1870676 | NEGR1 | -0.305 | 0.065 | 0.737 | 2.84x10-6 | 2797 | 633 | 2164 |
278 | Overweight, Obesity | rs9424977 | NEGR1 | -0.303 | 0.065 | 0.739 | 2.87x10-6 | 2816 | 639 | 2177 |
250.4 | Abnormal glucose | rs1776012 | NEGR1 | -0.444 | 0.095 | 0.642 | 3.20x10-6 | 2664 | 272 | 2392 |
250.4 | Abnormal glucose | rs1870676 | NEGR1 | -0.444 | 0.096 | 0.642 | 3.58x10-6 | 2655 | 270 | 2385 |
250.4 | Abnormal glucose | rs9424977 | NEGR1 | -0.424 | 0.095 | 0.655 | 7.81x10-6 | 2674 | 273 | 2401 |
564 | Functional digestive disorders | rs750456 | CABP5 | 0.989 | 0.229 | 2.689 | 1.55x10-5 | 2518 | 40 | 2478 |
278.11 | Morbid Obesity | rs2241005 | KLRB1 | -0.321 | 0.075 | 0.725 | 1.64x10-5 | 2625 | 445 | 2180 |
278.11 | Morbid Obesity | rs2058426 | N/A | -0.322 | 0.075 | 0.725 | 1.66x10-5 | 2621 | 445 | 2176 |
278.1 | Obesity | rs2568958 | N/A | -0.294 | 0.070 | 0.745 | 2.89x10-5 | 2781 | 601 | 2180 |
278.1 | Obesity | rs2815752 | N/A | -0.294 | 0.070 | 0.745 | 2.89x10-5 | 2781 | 601 | 2180 |
564.1 | Irritable Bowel Syndrome | rs750456 | CABP5 | 0.992 | 0.238 | 2.697 | 2.98x10-5 | 2515 | 37 | 2478 |
278.11 | Morbid Obesity | rs1870676 | NEGR1 | -0.315 | 0.075 | 0.730 | 3.06x10-5 | 2605 | 441 | 2164 |
278.1 | Obesity | rs3101336 | N/A | -0.293 | 0.070 | 0.746 | 3.08x10-5 | 2781 | 601 | 2180 |
278.11 | Morbid Obesity | rs1776012 | NEGR1 | -0.315 | 0.076 | 0.730 | 3.14x10-5 | 2606 | 438 | 2168 |
250.2 | Type 2 Diabetes | rs2246606 | TDH | -0.468 | 0.115 | 0.626 | 4.98x10-5 | 2591 | 187 | 2404 |
278.1 | Obesity | rs2953802 | N/A | 0.266 | 0.066 | 1.305 | 5.13x10-5 | 2781 | 601 | 2180 |
278.11 | Morbid Obesity | rs9424977 | NEGR1 | -0.304 | 0.075 | 0.738 | 5.21x10-5 | 2620 | 443 | 2177 |
278 | Overweight, Obesity | rs2568958 | N/A | -0.274 | 0.068 | 0.760 | 5.88x10-5 | 2821 | 641 | 2180 |
278 | Overweight, Obesity | rs2815752 | N/A | -0.274 | 0.068 | 0.760 | 5.88x10-5 | 2821 | 641 | 2180 |
278 | Overweight, Obesity | rs3101336 | N/A | -0.273 | 0.068 | 0.761 | 6.27x10-5 | 2821 | 641 | 2180 |
250.2 | Type 2 Diabetes | rs2736280 | TDH | -0.452 | 0.114 | 0.636 | 7.48x10-5 | 2588 | 187 | 2401 |
250 | Diabetes Mellitus | rs2246606 | TDH | -0.447 | 0.114 | 0.639 | 8.11x10-5 | 2596 | 192 | 2404 |
250.2 | Type 2 Diabetes | rs2953802 | N/A | 0.431 | 0.110 | 1.539 | 8.90x10-5 | 2591 | 187 | 2404 |
250.4 | Abnormal glucose | rs2568958 | N/A | -0.389 | 0.100 | 0.678 | 1.08x10-4 | 2678 | 274 | 2404 |
250.4 | Abnormal glucose | rs2815752 | N/A | -0.389 | 0.100 | 0.678 | 1.08x10-4 | 2678 | 274 | 2404 |
278 | Overweight, Obesity | rs2241005 | KLRB1 | -0.247 | 0.064 | 0.781 | 1.11x10-4 | 2821 | 641 | 2180 |
250.4 | Abnormal glucose | rs3101336 | N/A | -0.388 | 0.101 | 0.678 | 1.12x10-4 | 2678 | 274 | 2404 |
278.1 | Obesity | rs2241005 | KLRB1 | -0.253 | 0.066 | 0.776 | 1.14x10-4 | 2781 | 601 | 2180 |
278.1 | Obesity | rs2058426 | N/A | -0.250 | 0.066 | 0.779 | 1.43x10-4 | 2777 | 601 | 2176 |
278 | Overweight, Obesity | rs2058426 | N/A | -0.243 | 0.064 | 0.784 | 1.46x10-4 | 2817 | 641 | 2176 |
250 | Diabetes Mellitus | rs2736280 | TDH | -0.426 | 0.112 | 0.653 | 1.48x10-4 | 2593 | 192 | 2401 |
250.41 | Impaired fasting glucose | rs1870676 | NEGR1 | -0.471 | 0.125 | 0.625 | 1.59x10-4 | 2535 | 150 | 2385 |
278.11 | Morbid Obesity | rs2953802 | N/A | 0.278 | 0.074 | 1.321 | 1.76x10-4 | 2625 | 445 | 2180 |
250 | Diabetes Mellitus | rs2953802 | N/A | 0.407 | 0.109 | 1.502 | 1.77x10-4 | 2596 | 192 | 2404 |
250.41 | Impaired fasting glucose | rs1776012 | NEGR1 | -0.464 | 0.124 | 0.629 | 1.80x10-4 | 2543 | 151 | 2392 |
401.1 | Essential Hypertension | rs2948300 | N/A | 0.282 | 0.078 | 1.326 | 3.02x10-4 | 2737 | 521 | 2216 |
278 | Overweight, Obesity | rs2953802 | N/A | 0.231 | 0.064 | 1.260 | 3.06x10-4 | 2821 | 641 | 2180 |
250.2 | Type 2 Diabetes | rs2572386 | FAM167A | -0.415 | 0.115 | 0.660 | 3.15x10-4 | 2590 | 187 | 2403 |
497 | Bronchitis | rs1620977 | NEGR1 | 0.673 | 0.188 | 1.960 | 3.47x10-4 | 2118 | 60 | 2058 |
250.41 | Impaired fasting glucose | rs9424977 | NEGR1 | -0.441 | 0.124 | 0.644 | 3.60x10-4 | 2552 | 151 | 2401 |
278.11 | Morbid Obesity | rs2568958 | N/A | -0.283 | 0.079 | 0.753 | 3.66x10-4 | 2625 | 445 | 2180 |
278.11 | Morbid Obesity | rs2815752 | N/A | -0.283 | 0.079 | 0.753 | 3.66x10-4 | 2625 | 445 | 2180 |
278.11 | Morbid Obesity | rs3101336 | N/A | -0.282 | 0.080 | 0.754 | 3.85x10-4 | 2625 | 445 | 2180 |