Table 1.
Test sensitivity (when applied to brain tissue) relative to confirmatory methods. Published data from other studies are summarized in the lower half of the table for ease of comparison.
| Reference | n | Test sensitivity | |||
|---|---|---|---|---|---|
| IDEXX BOV | IDEXX SR | Bio-Rad SG | Bio-Rad TeSeE | ||
| Current study | |||||
| Total sample set* | 128 | 108/128† (84.4%) (77.1–89.6%‡) |
106/128 (82.8%) (75.3–88.4%) |
94/128 (73.4 %) (65.1–80.3%) |
55/73 (75.3%) (64.3–83.8%) |
| Clinically affected | 41 | 41/41 (100%) (91.4–100%) |
41/41 (100%) (91.4–100%) |
41/41 (100%) (91.4–100%) |
40/41 (97.4%) (87.4–99.5%) |
| Preclinical animals or of unknown clinical status | 87 | 65/87 (74.7%) (64.6–82.6%) |
65/87 (74.7%) (64.6–82.6%) |
53/87 (60.9%) (50.4–70.5%) |
15/32 (46.8%) (30.8–63.5%) |
| UK herd cull16 | 34 | 56%* | |||
| 68 | 27.9%§ | ||||
| French surveillance | |||||
| Lab 18 | 180 | 47.3%* § | |||
| Lab 28 | 58.4%* § | ||||
| European scrapie cases21 | 61 | 96.7%¦ | 83.6%¦ | 85.2%¦ | |
*
All positive samples from clinically normal as well as suspect and unknown clinical status animals.
†
No. of test-positive animals/no. of TSE-positive animals.
‡
Confidence intervals of the proportions (sensitivity).
§ Includes animals positive only in lymphoreticular tissues.
¦ Sensitivity is reported as 100% for animals showing clinical signs.