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Potential methods of avoiding the side effects of anti-CD47 treatments. To reduce side effects of treatment with anti-CD47 antibodies, investigators could use: (A) antibody fusion proteins e.g., TTI-621 (133) or ALX-148 (134); (B) “initiation doses” followed by “therapeutic doses” e.g., Hu5F9-G4 (111); (C) pro-drug vesicle-induced immunogenic cell death combined with CD47 blockade (78); or (D) tumor-targeting nanoparticles loaded with anti-CD47 antibody (135).
