Table 2.
Crude incidence rates and adjusted HRs of ESKD comparing the risk between the time-periods after CVD and free of CVD
| ESKD Risk | All CVD Subtypes Combined (2598 events) | CVD Subtypes | |||
|---|---|---|---|---|---|
| Heart Failure (1269 Events) | Atrial Fibrillation (1337 Events) | Coronary Heart Disease (696 Events) | Stroke (559 Events) | ||
| Person-yr when free of relevant CVD (×103) | 106.0 | 127.5 | 124.6 | 135.2 | 137.6 |
| ESKD cases | 76 | 97 | 163 | 172 | 194 |
| Incidence rate per 1000 person-yra | 0.7 (0.6–0.9) | 0.8 (0.6–0.9) | 1.3 (1.1–1.5) | 1.3 (1.1–1.5) | 1.4 (1.2–1.6) |
| Person-yr after relevant CVD (×103) | 40.0 | 18.5 | 21.4 | 10.8 | 8.4 |
| ESKD cases | 134 | 113 | 47 | 38 | 16 |
| Incidence rate per 1000 person-yra | 3.3 (2.8–4.0) | 6.1 (5.1–7.3) | 2.2 (1.6–2.9) | 3.5 (2.6–4.8) | 1.9 (1.2–3.1) |
| HR (95% CI) | |||||
| Model 1 | 11.61 (8.61 to 15.65) | 22.91 (17.13 to 30.64) | 4.21 (2.99 to 5.93) | 4.91 (3.42 to 7.03) | 2.27 (1.35 to 3.80) |
| Model 2 | 6.63 (4.88 to 9.00) | 11.40 (8.38 to 15.50) | 2.66 (1.87 to 3.79) | 3.67 (2.53 to 5.33) | 1.44 (0.85 to 2.44) |
| Model 3 | — | 9.92 (7.14 to 13.79) | 1.10 (0.76 to 1.60) | 1.80 (1.22 to 2.66) | 1.09 (0.65 to 1.85) |
Model 1 adjusted for age, sex, and race. Model 2 additionally adjusted for body mass index, ever smoking, ever drink, years of education, systolic BP, antihypertensive drugs, diabetes, eGFR, ACR, CRP, total cholesterol, HDL-C, and history of COPD and cancer, with covariates updated when available. Model 3 additionally adjusted for CVD subtypes (e.g., atrial fibrillation, coronary heart disease, and stroke for analysis of heart failure).
a
Data in parentheses displayed as 95% CI.