Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 9;31(2):309–323. doi: 10.1681/ASN.2019030289

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 by the American Society of Nephrology

PMC Copyright notice

Figure 4. — FSKAT gene-level analysis identifies genes associated with DN in core podocyte network. (A) Graphical representation of the core podocyte network that includes the genes associated with DN by F-SKAT analysis in the discovery cohort. Node color indicates the statistical significance (P value) of the F-SKAT test. White color nodes indicates podocyte network genes not detected in this study. (B) The F-SKAT–associated genes within the podocyte network are enriched (adjusted P<0.05) for several pathways; top six pathways and contributing genes are reported. Full functional enrichment results are reported in Supplemental Table 6. (C) Details on the PRKCE gene that showed the highest association with DN (by F-SKAT) and location of the intronic SNVs associated with DN. For each SNV, the association with DN is reported by OR tested in either a recessive or dominant model. Full statistics and regulatory information on the SNVs are reported in Supplemental Table 4B.