Table 1.
Baseline characteristics of cohort
| Variable | Reference, n=8,729 | SCT, n=1,251 | P Value | SCD, n=230 | P Value |
|---|---|---|---|---|---|
| Demographics | |||||
| Mean age (SD), yr | 36 (±12) | 40 (±14) | <0.01 | 33 (±12) | <0.01 |
| Age ≥65 yr | 3% | 7% | <0.01 | 1% | 0.01 |
| Women | 88% | 78% | <0.01 | 50% | <0.01 |
| Median follow-up (IQR), yr | 8.1 (4.6–11.3) | 8.5 (4.7–11.6) | 0.04 | 7.3 (4.2–11.4) | 0.21 |
| Comorbidities | |||||
| Hypertension | 20% | 30% | <0.01 | 11% | <0.01 |
| DM | 16% | 25% | <0.01 | 10% | <0.01 |
| CVD | 10% | 14% | <0.01 | 28% | <0.01 |
| Smoking | <0.01 | <0.01 | |||
| Never | 50% | 45% | 39% | ||
| Ever | 16% | 14% | 9% | ||
| Missing | 34% | 41% | 52% | ||
| AKI | 7% | 13% | <0.01 | 25% | <0.01 |
| Medications | |||||
| ACEis/ARBs | 20% | 29% | <0.01 | 21% | 0.75 |
| Aspirin | 28% | 22% | <0.01 | 35% | <0.01 |
| Statins | 15% | 23% | <0.01 | 12% | 0.15 |
| Hydroxyurea | 0.2% | 0.3% | 0.21 | 48% | <0.01 |
| Laboratory | |||||
| Mean eGFR (SD), ml/min per 1.73 m2 | 114 (±26) | 103 (±27) | <0.01 | 128 (±32) | <0.01 |
| eGFR categories | <0.01 | <0.01 | |||
| ≥120 ml/min per 1.73 m2 | 45% | 30% | 66% | ||
| 90–119 ml/min per 1.73 m2 | 36% | 40% | 22% | ||
| 60–89 ml/min per 1.73 m2 | 16% | 25% | 8% | ||
| 30–59 ml/min per 1.73 m2 | 3% | 5% | 4% | ||
| Urine ACR | <0.01 | 0.32 | |||
| <30 mg/g | 2% | 3% | 1% | ||
| 30–299 mg/g | 1% | 2% | 0% | ||
| >300 mg/g | 0% | 0% | 0% | ||
| Missing | 97% | 95% | 99% | ||
| Mean hemoglobin (SD), g/dla | 12.3 (±1.6) | 12.6 (±1.7) | <0.01 | 9.9 (±2.1) | <0.01 |
| Mean leukocyte count (SD), ×105 cells/mm3a | 7.6 (±3.4) | 7.2 (±3.0) | <0.01 | 12.3 (±6.4) | <0.01 |
| Hemoglobin electrophoresis indications | <0.01 | — | — | ||
| Anemia | 39.4% | 24.5% | — | — | |
| Perinatal testing | 51.8% | 37.9% | — | — | |
| Other | 3.4% | 16.8% | — | — | |
| Unknown | 5.4% | 20.8% | — | — | |
| Mean HbS percentage (SD) | — | 37.0 (±4.3) | — | — | — |
| HbF>0.4% | — | 24.6% | — | — | — |
| Mean HbA percentage levels (SD) | — | 59.4 (±4.4) | — | — | — |
| Mean HbA2 percentage (SD) | — | 3.2 (±0.7) | — | — | — |
AKI was during follow-up; eGFR was obtained using CKD-EPI creatinine equation.
a
Missing data: hemoglobin (13 reference, 8 SCT, and 0 SCD), leukocyte count (1422 reference, 227 SCT, and 18 SCD), HbS (21), HbF (77), HbA (23), and HbA2 (74).