Table 2.

Association statistics comparing PMG with controls for four common variants in complement genes previously described at altered frequency in individuals with aHUS/MPGN

Chr	Position	Ref	Alt	rsID	Gene	HGVSp	Case	Control	gnomAD-NFE	OR (95% CI)	P Value
1	196654324	A	C	rs1061147	CFH	p.A307A	0.534	0.620	0.617	0.71 (0.56 to 0.89)	3.5×10−3
1	196659237	C	T	rs1061170	CFH	p.H402Y	0.534	0.620	0.616	0.71 (0.56 to 0.89)	3.4×10−3
19	6713262	G	A	rs1047286	C3	p.P314L	0.284	0.213	0.200	1.47 (1.13 to 1.90)	3.9×10−3
19	6718387	G	C	rs2230199	C3	p.R102G	0.295	0.218	0.206	1.49 (1.16 to 1.93	2.1×10−3

The two chromosome 19 variants and two chromosome 1 variants are in linkage disequilibrium (r²=0.844 and r²=0.999, respectively). Chr, chromosome; Ref, reference allele; Alt, alternate allele; rsID, dbSNP identifier; HGVSp, HGVS protein sequence change; gnomAD-NFE, allele frequency in non-Finish Europeans in the gnomAD database; Position, reference and alternate alleles are given with reference to Build 37 of the human genome.