Table 1.

CFHR Gene Variations in aHUS Affect FHR and Factor H but not FHL1 Plasma Levels

Variable	Intact FHL1	Affected				Intact
		Factor H		FHR3	FHR1	FHR 4	FHR2	FHR5
Factor HFHR3	100	50	Factor HFHR3	50	100	100	100	100
Factor HFHR3	100	50	Factor HFHR3	50	100	100	100	100
Factor HFHR1	100	50	Factor HFHR1	100	50	100	100	100
Factor HFHR1	100	50	Factor HFHR1	100	50	100	100	100
FHR1::Factor H	100	100	FHR1::Factor H	150	100	100	100	100
FHR1::Factor H	100	100	FHR1::Factor H	150	100	100	100	100
ΔΔFHR3FHR1	100	100		0	0	100	100	100
ΔFHR3FHR1	100	100		50	50	50	100	100
ΔΔFHR1FHR4	100	100		100	0	0	100	100

Numerical data presented as % plasma levels.