Figure 5.

B1R deficiency in BM-derived cells reduces anti-MPO–induced glomerular crescents, and glomerular influx of neutrophils and monocytes. At 6 days after injection of anti-MPO IgG, kidney samples of experimental groups were evaluated for percent of glomeruli with crescents, and percent of glomeruli containing neutrophils and monocytes. WT B6 mice injected with anti-MPO had more glomeruli with crescents, and more with neutrophil and monocytes compared with B1R^−/− mice (two panels on the left). Chimeric B1R^−/− mice that received WT (B1R^+/+) BM (n=8) injected with anti-MPO had more glomeruli with crescents, and more with neutrophil and monocytes compared with chimeric WT mice that received B1R^−/− BM (n=6).