Table 3.

LncRNAs dysregulated in pancreatic cancer

LncRNA	RNA description	Expression in PC	Functions in cancers	References
HOTAIR	LncRNA HOX transcript antisense RNA	Up	Related to cancer cell proliferation, progression and invasion	[4]
HOTTIP	HOXA transcript at the distal tip	Up	Promotes cancer cell proliferation, inhibits cell apoptosis, increases migration	[54]
MALAT-1	Metastasis-associated lung adenocarcinoma transcript 1	Up	Regulates the cell cycle, growth, migration and invasion	[19]
H19	LncRNA H19	Up	Enhances pancreatic cancer cell proliferation	[90]
ENST00000480739	LncRNA ENST00000480739	Down	Cell proliferation, invasion and migration	[69]
BC008363	LncRNA BC008363	Down	Potential critical role in tumorigenesis	[84]
PVT1	Plasmacytoma variant translocation 1	Up	Unknown	[75]
GAS5	Growth arrest-specific 5	Down	Inhibits cell proliferation	[86]
NEAT1	p53-inducible lincRNA	Down	Promotes neoplasia	[65]
SNHG 15 16	Small nucleolar RNA host gene	Up	Regulation of cell proliferation, migration and invasion of tumors	[59, 61]
ZEB2-AS1	LncRNA ZEB2-AS1	Up	Cell growth and invasion	[79]
TUG1	Taurine upregulated 1	Up	Cell proliferation, invasion, and migration	[73, 74]
XIST	LncRNA X inactive-specific transcript	Up	Promotes proliferation, migration and invasion	[25]
MEG3	LncRNA MEG3	Down	Tumor suppressor	[91, 92]
DUXAP8	A pseudogene-derived lncRNA	Up	Cell proliferation and promotes apoptosis in vitro and in vivo	[70]
XLOC-000647	LncRNA XLOC-000647	Down	Cell proliferation and invasion	[63]
IRAIN	LncRNA IRAIN	Up	Cell apoptosis and induces growth arrest	[66]
DLEU2	LncRNA DLEU2	Up	Cell proliferation and invasion	[12]
HULC	LncRNA HULC	Up	Cell proliferation, migration and invasion	[68]
PCTST	LncRNA PCTST	Down	Inhibits cell proliferation, invasion, tumorigenesis and EMT	[73]