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. 2020 Feb 5;21:77. doi: 10.1186/s12891-020-3091-1

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Bone mass decreased in vertebral bone of db/db mice indcued by leptin receptor knock out. (A) Representative μCT scans of the fifth lumbar spine showing the 3D reconstructed trabecular bones. (B) (a) Quantitative analysis of the percentage of bone marrow density (BMD). (b) Quantitative analysis of the percentage of bone volume (BV/TV) (c) Quantitative analysis of trabecular thickness (Tb.Th). (d) Quantitative analysis of trabecular spacing (Tb.Sp). (e) Quantitative analysis of trabecular number (BV/TV). All analyses were performed with 5 mice per group. All data are reported as the mean ± s.d. Statistical significance was determined by three-way ANOVA and Student’s t-test. NS = not significant. ^*P < 0.05 (IGF-1 group compare to WT). ^#P < 0.05(db/db group compare to WT)