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. 2020 Feb 5;21:77. doi: 10.1186/s12891-020-3091-1

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Incresed cell apoptosis in intervertebral disc cells of db/db mice indcued by leptin receptor knock out. a, b, c Representative TUNEL assay shows cell death for the intervertebral disc in WT, IGF treated and db/db group. d Quantitative analysis of the percentage of TUNEL-positive cells to the total cells per view in (a, b, c). (N = 5, triplicates per group). All data are reported as the mean ± s.d. Statistical significance was determined by three-way ANOVA and Student’s t-test. ^*P < 0.05(IGF-1 treated group compare to WT). ^#P < 0.05(db/db group compare to WT). ^aP < 0.05(IGF-1 treated compare to db/db group)