Figure 3.

Hypothetical example of the qualification of clinical relevance of performance differences between patients and controls. The dotted line indicates the change in performance after alcohol intake (relative to placebo). A (drug induced) change in performance will be classified as inferior when the 95% confidence interval (CI) includes the alcohol criterion but not zero (A—inferiority). Noninferiority is concluded when the 95% CI does not include the alcohol criterion (B—noninferiority). If the 95% CI includes the alcohol criterion as well as zero, the qualification of clinical relevance is undecided (C—inconclusive). BAC, blood alcohol concentration