Table 4.
. Mean (95% confidence interval) differences in alcohol calibrated neurocognitive parameters between patient and control groups and noninferiority analysis
| Parameters | Noninferiority limit |
Anxiolytics N = 12 |
Hypnotics N = 32 |
Hypnotics LT3− N = 9 |
Hypnotics LT3+ N = 23 |
||||
|---|---|---|---|---|---|---|---|---|---|
| TMT‐A (s) | +2.72 | +2.9 (−7.1, +12.9) | Inc | +5.3 (−1.2, +11.7) | Inc | −0.9 (−9.9, +8.0) | Inc | +7.7 (−0.5, +15.9) | Inc |
| DSST (number correct) | −1.38 | +13.8 (−17.6, +39.7) | Inc | −8.6 (−13.9, −3.2) | Inf | −14.1 (−25.7, −2.6) | Inf | −6.7 (−12.9, −0.5) | Inf |
| RT‐S1 | |||||||||
| Reaction time (ms) | +10.35 | +6 (−28, +41) | Inc | +38 (+6, +70) | Inf | +62 (−34, +157) | Inc | +28 (−1, +58) | Inc |
| RT‐S2 | |||||||||
| Reaction time (ms) | +7.83 | −6 (−35, +22) | Inc | +32 (+1, +62) | Inf | +72 (+2, +141) | Inf | +17 (−18,+51) | Inc |
| RT‐S3 | |||||||||
| Reaction time (ms) | +23.82 | −7 (−68, +55) | Inc | +62 (+11, +112) | Inf | +116 (+8, +224) | Inf | +40 (−18, +99) | Inc |
| DT | |||||||||
| Reaction time (ms) | −9.14 | +127 (+25, +229) | Inf | +109 (+44, +175) | Inf | +146 (+5, +286) | Inf | +98 (+21, +175) | Inf |
| PVT | |||||||||
| Mean RT (ms) | +19.36 | +39 (+15, +64) | Inf | +22 (+6, +39) | Inf | +31 (+2, +60) | Inf | +20 (+4, +35) | Inf |
| Lapses (number) | +1.71 | +1.8 (−0.3, +3.9) | Inc | +1.4 (−1.1, +3.9) | Inc | +3.9 (−5.3, +13.1) | Inc | +0.6 (−1.3, +2.4) | Inc |
Abbreviations: DSST, Digit Symbol Substitution Test; DT, Determination Test; Inc, inconclusive; Inf, inferiority; LT3−, patients treated less than 3 years; LT3+, patients treated longer than 3 years; PVT, Psychomotor Vigilance Test; RT, Reaction Test; TMT, Trail Making Test.