Supplementry Table 8.
DN-associated genes are manually retrived from literature. For each miRNA, validated and predicted tragets known to be DN-associated are listed.
| Glomerule Compartment | Tubulointerstitium Compartment | |||||
|---|---|---|---|---|---|---|
| DN assosiated genes | microRNA | Common genes between validated targets and DN gene list | Common genes between predicted targets and DN gene list | microRNA | Common genes between validated targets and DN gene list | Common genes between predicted targets and DN gene list |
| Vegf | hsa-miR-590-5p | TGFBR2,SMAD3,SMAD7,FOXN2,FOXO3,PDCD4,TGFB1 | PPP3CA,SERP1 | hsa-miR-208a | LEP,CYP1B1,FOXP1,MAK16,MAP3K5,MAPK10, | TGFBR1,COL4A3,FNIP1,FOXG1,FOXP2,MAP3K2,MMP16,PPP3CB,PRKAR1A,ZEB2 |
| Fox | hsa-miR-921 | ANGPTL1,FOXN3,TNFAIP8L1 | MAP2K6,MAPK1 | hsa-miR-921 | ANGPTL1,FOXN3,PRKG1,TNFAIP8L1 | MAPK1 |
| Hif | hsa-miR-505 | PRKCA,ACER2,COL4A1,FOXE1 | MAPK1IP1L,PTEN,TNFSF11 | hsa-miR-496 | AKT1,COL19A1,FOXA1,FOXN2,LEPROTL1,MAPK8,PPP6C | TGFBR2,FOXN2,PPP6C,TNFRSF10D |
| Cyp | hsa-miR-383 | ADIPOQ,AGTRAP,ANGEL2,ANGPT4,COL8A1,CYP20A1,CYP51A1 | PRKAG1,VEGFA | hsa-miR-590-5p | TGFBR2,SMAD3,SMAD7,FOXN2,FOXO3,TGFB1 | PPP3CA,SERP1 |
| Ace2 | hsa-miR-3152-3p | PPP2CA,MAPK10,PPP1R16B | SMAD2,TGFBR1,ADI1,MMP16,TGFBR1,TNFSF14 | hsa-miR-3146 | IGF2R,PPP1R15B | COL4A4,SMAD9 |
| Adipoq | hsa-miR-4259 | COL18A1 | CYP20A1,HIP1,TNFRSF14 | hsa-miR-331-5p | SOD2,PPP1R1A | MAP2K6,MAP3K1,PDGFD,PRKAB2,SMAD2 |
| Agt | hsa-miR-4327 | HIF1AN,LEPROT,MAPK1IP1L | PTEN | hsa-miR-4484 | MAPKAPK5 | SOD3,FOXE1,SMAD4,SOD3, |
| Akr1b3 | hsa-miR-4445 | SOD2 | PPP2CA | hsa-miR-4637 | SOD2,FOXN3,PPP1R3G | TMEM236,PPP1R2 |
| Akt1 | hsa-miR-1284 | FGF2 | AKTIP | hsa-miR-4684-3p | PPP3R1 | PPP1R15B,PRKAA2,ZEB2 |
| Bdkrb1 | hsa-miR-4718 | IGF2BP1,PRKCB | ACER3,MAP2K6 | hsa-miR-4704-5p | MAP10,TNFSF15 | MAP2K4,SMAD9 |
| Col1a1 | hsa-miR-4423-3p | IGF1R,PPP1R2 | AGTRAP,PPP4R1L | hsa-miR-550b | PPP2CA,FOXA1,IGFBP5,MAPK1 | PPP2CA |
| Col2a1 | hsa-miR-501-3p | SOD2,COL23A1,CYP4F11 | COL10A1,PPP2R2C,PPP2R5E,PPP4R2 | hsa-miR-584 | LEP,CYP1B1,FOXP1,MAP3K5,MAPK10 | COLQ,FNDC3A,PPP6C |
| Col3a1 | hsa-miR-502-3p | SOD2 | hsa-miR-208b | SOD2,COL23A1,HIF1AN | COLEC10,SMAD4 | |
| Col4a1 | hsa-miR-508-3p | FLOT2,PPP1R15B | hsa-miR-4474-5p | MAP9 | PPP1R12B | |
| Ctgf | hsa-miR-3682-3p | COL4A4,MAP2K6,PPP1R12B | hsa-miR-770-5p | COL19A1,TNFAIP1, | COL4A4,MAP2K6,PPP1R12B | |
| Fn1 | hsa-miR-4694-5p | FOXN3,PRKCA,PTEN | hsa-miR-3689a-5p | SOD2 | ||
| Icam1 | hsa-miR-4445 | |||||
| Jun | ||||||
| Lep | ||||||
| Lepr | ||||||
| Mapk14 | ||||||
| Mmp9 | ||||||
| Nos3 | ||||||
| Pdgfb | ||||||
| Pdgfc | ||||||
| Pdgfd | ||||||
| Ppara | ||||||
| Ppp2ca | ||||||
| Prkca | ||||||
| Pten | ||||||
| Serpine1 | ||||||
| Smad2 | ||||||
| Smad3 | ||||||
| Smad7 | ||||||
| Sod2 | ||||||
| Sod3 | ||||||
| Spp1 | ||||||
| Srebf1 | ||||||
| Tgfb2 | ||||||
| Tgfbr1 | ||||||
| Tgfbr2 | ||||||
| Tgfbr3 | ||||||
| Tnf | ||||||
| Zeb1 | ||||||
| Yap | ||||||
| Foxn | ||||||
| Pdcd4 | ||||||
| Mmp9 | ||||||
| Ogg | ||||||
| Ros | ||||||