| Study | Reason for exclusion |
|---|---|
| Abejar 1993 | Not an RCT |
| Arav‐Boger 1994 | Patients with different colony counts were included. |
| Arcieri 1987 | Systematic review, but it was impossible to extract any individual data or sufficiently evaluate individual data. |
| Auquer 2002 | Different treatment durations (single dose 500 mg ciprofloxacin versus 3 days norfloxacin 400 mg twice daily). |
| Backhouse 1989 | Both men and women were included in the study population. |
| Banya 1985 | The study was not controlled. |
| Beringer 1997 | The article does not describe original studies. It is impossible to separate data from UTI studies. |
| Bernal 2002 | Different treatment durations of the same fluoroquinolone (3 days versus 7 days norfloxacin 400 mg twice daily). |
| Blomer 1986 | Combines data from different studies of ofloxacin. Only one is a comparison between quinolones, but it is impossible to clarify if the study was randomised and to extract study description. |
| Bottino 1989 | Different doses of the same fluoroquinolone (300 mg and 600 mg ofloxacin for 3 days). |
| Bouffioux 1982 | 1. Both men and women were included in the study population. 2. Patients with pyelonephritis were included. |
| Boyko 1990 | Patients with baseline pathogens resistance to study drugs were excluded. |
| Briedigkeit 1982 | Not an RCT |
| Bucy 1981 | Not an RCT |
| Cortes 1992 | Study was not randomised although stated in the article. There were three arms in study (fosfomycin versus pipemidic acid versus norfloxacin). The ratio of the patient in the groups was 49:36:21. The rate of this kind cannot be in randomised study. Microbiological criteria for patients inclusion into study was not been defined. |
| Cox 1982 | The study was not comparative. |
| Craft 1991 | Different treatment durations (3 days temafloxacin 400 mg once daily versus 7 days). |
| Dawani 1987 | Not an RCT |
| De Miranda 1995 | Not comparative study |
| Del Rio 1996 | Different treatment durations of two fluoroquinolones (single dose rufloxacin 400 mg versus 3 days norfloxacin 400 mg twice daily). |
| Derevianko 1996 | The study was not controlled. |
| Drylie 1981 | 1. Not an RCT 2. It is impossible to determinate if only uncomplicated UTI were included into the study. |
| Fujita 1993 | Not comparative study. |
| Gallego Gomez 1987 | Not an RCT |
| Giamarellou 1984 | 1. Both men and women were included in the study population. 2. Both patients with complicated and uncomplicated UTI were included. |
| Goldstein 1987 | 1. Both men and women were included in the study population. 2. Both patients with complicated and uncomplicated UTI were included. 3.Patients with baseline pathogens resistant to study drugs were excluded. |
| Goto 1999 | 1. It is impossible to determine if patients with uncomplicated UTI only were included. 2. There is not clearly description of the randomisation procedure. |
| Guibert 1997 | Microbiological evaluation was absent. Urine culture was not used. |
| Henry 1999 | Different treatment durations (singe dose sparfloxacin versus 3 day sparfloxacin versus 7 day ciprofloxacin). |
| Hirose 1992 | Different doses of the same fluoroquinolone (100 mg and 200 mg sparfloxacin for 3 days). |
| Huilin 2000 | Nosocomial UTI were evaluated. |
| Iravani 1996 | Different treatment durations were compared (singe dose sparfloxacin versus 3 day sparfloxacin versus 7 day ciprofloxacin). |
| Iravani 1991 | Results from 3 studies were summarized. In one study fluoroquinolone (temafloxacin) was compared with co‐trimoxazole and it is impossible to separate the data from individual study. |
| Iravani 1992 | 1. Both men and women were included in the study population. 2. Patients with baseline pathogens resistant to study drugs were excluded. |
| Ishigami 1976 | Not an RCT |
| Ishihara 1998 | Different treatment durations of the same fluoroquinolone (3 days versus 7 days fleroxacin). |
| Kadiri 1999 | 1. Both men and women were included in the study population. 2. Microbiological evaluation as inclusion criteria was absent. 3. The randomisation procedure was not described. |
| Karachalios 1991 | Included patients both with acute and recurrent cystitis. |
| Koyama 2000 | Different treatment durations of the same fluoroquinolone (singe dose versus 3 days levofloxacin). |
| Kumamoto 1983 | Different doses of the same fluoroquinolone (800 mg, 400 mg, 200 mg and 100 mg cinoxacin for 3 days). |
| Leelarasamee 1995 | Different treatment durations of the same fluoroquinolone (single dose of pefloxacin versus 3 days pefloxacin). |
| Leibovici 1991 | Meta‐analysis, quinolones were not compared. |
| Loran 1997 | Not an RCT |
| Ludwig 1996 | There are 4 studies in the article. Only one of them compares Fluoroquinolones, but they were used in different treatment durations (single dose ofloxacin versus 3 days ofloxacin) and the study is not randomised. |
| Malinverni 1988 | Systematic review. References to some studies were used. |
| Martorana 1988 | Not comparative study |
| Matsuura 1985 | Not comparative study |
| Miano 1990 | The study is a non‐systematic review. The information from as comparative and non‐comparative studies was combined. Both men and women were included in the study population. |
| Miyata 1987 | Not comparative study |
| Naber 1994 | The publication is a meta‐analysis. Only one included study compares two quinolones but there are no mention if the randomisation taken place. |
| Naber 1996 | 1. Both men and women were included in the study population. 2. Both patients with complicated and uncomplicated UTI were included. |
| Nagai 1988 | The trial was not comparative. The trial included the patients both with acute and chronic complicated cystitis |
| Nordic 1988 | Different treatment durations of the same fluoroquinolone (3 days versus 7 days norfloxacin). |
| Norrby 1990b | Systematic review, quinolones were not compared. |
| Ohmori 1989 | Not an RCT |
| Ohmori 1998 | Not an RCT |
| Piipo 1990 | Different treatment durations of the same fluoroquinolone (3 days versus 7 days norfloxacin). |
| Pimentel 1998 | Different treatment dosage of the same fluoroquinolone (7‐10 day norfloxacin 800 mg once daily versus 400 mg twice daily). |
| Pytel' 1996 | Not controlled study |
| Raz 1989 | The trial included the patients with as acute and recurrent cystitis. |
| Reeves 1984 | 1. Both men and women were included in the study population. 2. The appropriate differentiation between lower and upper UTI was absent, so patients with both lower and upper UTI could be included. |
| Rizk 1992 | This systematic review described two studies of uncomplicated cystitis in women, but there were no bibliographic references to appropriate publications. Authors did not describe individual data and characteristics of each study. |
| Saginur 1992 | Different treatment durations of the same fluoroquinolone (standard dose versus 3 days norfloxacin). |
| Schaeffer 1987 | Not comparative study |
| Stein 1992 | Different treatment durations (3 days temafloxacin versus 7 days ciprofloxacin). |
| Trienekens 1993 | Different treatment durations of the same fluoroquinolone (3 days norfloxacin versus 7 days norfloxacin). |
| Tsugawa 1999 | Different treatment durations of the same fluoroquinolone (3 days versus 7 days gatifloxacin). |
| van Balen 1990 | Different treatment durations (5 days norfloxacin versus single dose pefloxacin). |
| van Poppel 1988 | This article combined data from ciprofloxacin studies in different UTI types and with different study designs. There is impossible to extract individual study data and description. |
| Vogel 1984 | 1. Not an RCT 2. Both men and women were included in the study population. 3. There was no appropriate differentiation between lower and upper UTI, so patients with both lower and upper UTI could be included. |
| Wang 1986 | 1. It is non systematic review. 2. There were no original data concerning current systematic review. |
| Wittenberger 1986 | Not an RCT |
| Zerqueni 1984 | Both men and women were included in the study population. Complicated UTI were also studied |
RCT ‐ randomised controlled trial