Table 1.

Common Symptoms in Patients With Mast Cell Mediator Disorders

• Cardiovascular: chest pain, hypotension, hypotensive syncope, tachycardia

• Dermatologic: angioedema, dermatographism, flushing, pruritus, urticaria pigmentosa

• Gastrointestinal: abdominal crumping/pain, bloating, diarrhea, esophagitis, nausea, vomiting

• Musculoskeletal: bone/muscle pain, degenerative disc disease, osteoporosis/osteopenia

• Naso-ocular: nasal congestion, pruritus, tearing

• Neurologic: headache, memory and concentration difficulties (brain fog), paresthesias, peripheral neuropathy

• Respiratory: hoarseness, sore throat, stridor, throat swelling, wheezing

• Systemic: anaphylaxis, fatigue