Table 5.
Mast Cell Mediators
| Prestored |
| Biogenic Amines |
| Dopamine |
| Histamine |
| 5-Hydroxytryptamine (5-HT, serotonin) |
| Polyamines |
| Spermidine, spermine |
| Cytokines |
| TNF |
| Enzymes |
| Arylsulfatases A |
| Beta-hexosaminidase |
| Beta-glucuronidase |
| Beta-glucosaminidase |
| Beta-D-galactosidase |
| Carboxypeptidase A |
| Cathepsins B,C, D, E, L |
| Chymase |
| Garnzyme B |
| Kinogenases |
| Phospholipases |
| Renin |
| Tryptase |
| Metalloproteinases |
| (CPA3, MMP9, ADAMTSS) |
| Growth factors |
| FGF |
| NGF |
| SC |
| TGFβ |
| VEGF |
| Peptides |
| ACTH |
| Angiogenin |
| Angiopoietin |
| Calcitonin gene-related peptide |
| Corticotropin-releasing hormone |
| Endorphins |
| Endothelin |
| Hemokinin-1 |
| Kinins (bradykinin) |
| Leptin |
| Melatonin |
| Neurotensin |
| RANKL |
| Somatostatin |
| Substance P |
| Urocortin |
| Vasoactive intestinal peptide |
| Proteoglycans |
| Chondroitin sulfate |
| Heparan sulfate |
| Heparin |
| Hyaluronic acid |
| Serglin |
| De novo synthesized |
| Chemokines |
| IL-8 (CXCL8), MCP-1 (CCL2), MCP-3 (CCL7), |
| MCP-4, RANTES (CCL5), Eotaxin (CCL11) |
| Cytokines |
| IL-1β, IL-4, IL-5, IL-6, IL-15, IL-17, IL-31, IL-33, TNF |
| Growth Factors |
| SCF, β-FGF, neurotrophin 3, NGF, |
| PDGF, TGFβ, VEGF |
| Nitric oxide |
| Phospholipid metabolites |
| Leukotriene B4 |
| Leukotriene C4 |
| Platelet activating factor |
| Prostaglandin D2 |