Table 8.
Proposed Pathogenetic Mechanisms for Mast Cell Mediator Disorders
| Lower activation threshold due to decreased expression/function of inhibitory molecules/pathways. |
| Intracellular |
| PTEN ↓ |
| Chondroitin sulfate ↓ |
| Sergylin ↓ |
| Spermine/spermidine ↓ |
| TGF beta ↓ |
| Extracellular |
| Deflisinc ↓ |
| IL-10 ↓ |
| IL-37 ↓ |
| IL-38 ↓ |
| TGF beta ↓ |
| Combination of non-allergic triggers |
| Peptides and Cytokines |
| SP + IL-33 |
| NT + CRH |
| HK-1 + IL-33 |
| Unappreciated triggers |
| CRH |
| Borrelia toxin |
| Bradykinin |
| CGRP |
| RCAP |
| Mycotoxins |
| NGF |
| Poly (lic) |
| PTH |
| Stress |
| Autocrine effects |
| Secretion of autocrine mediators |
| CRH |
| NK-1 |
| Neurotensin |
| Tryptase |
| Autocrine receptor expression |
| Secretion of autocrine mediators |
| NT → CRHR-1 ↑ |
| SP → CRHR-1 ↑ |
| CRH → NTR ↑ |
| SP → STZ ↑ |
| IL-33 → NK-1 ↑ |