Table 1.
Burden of NMBM and IMD cases reported to the SNVS, by year, adjusted by coverage and diagnostic methods
| Number of cases per year (IRs per 100 000 inhabitants per year) | Year | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | Mean | |
| Reported | |||||||||||
| NMBM (ICD-10 code G00a) | 703 (1.76) | 765 (1.90) | 531 (1.30) | 644 (1.57) | 778 (1.87) | 699 (1.66) | 662 (1.56) | 682 (1.59) | 617 (1.42) | 526 (1.20) | 661 (1.58) |
| IMD (ICD-10 code A39b) | 142 (0.36) | 155 (0.38) | 97 (0.24) | 137 (0.33) | 205 (0.49) | 148 (0.35) | 183 (0.43) | 176 (0.41) | 116 (0.27) | 111 (0.25) | 147 (0.35) |
| Adjusted by coveragec | |||||||||||
| Adjusted NMBM | 1172 (2.94) | 1275 (3.16) | 885 (2.17) | 1073 (2.61) | 1297 (3.12) | 1165 (2.77) | 1103 (2.60) | 1137 (2.65) | 1028 (2.37) | 877 (2.01) | 1101 (2.64) |
| Adjusted IMD | 237 (0.59) | 258 (0.64) | 162 (0.40) | 228 (0.56) | 342 (0.82) | 247 (0.59) | 305 (0.72) | 293 (0.68) | 193 (0.45) | 185 (0.42) | 245 (0.59) |
| Adjusted by improved bacterial culture methodd | |||||||||||
| Additional Nm identified | 84 (0.21) | 91 (0.23) | 77 (0.19) | 68 (0.17) | 31 (0.08) | 75 (0.18) | 16 (0.04) | 32 (0.08) | 85 (0.20) | 57 (0.13) | 62 (0.15) |
| Adjusted NMBM | 1088 (2.73) | 1184 (2.94) | 808 (1.98) | 1005 (2.44) | 1265 (3.04) | 1090 (2.60) | 1087 (2.56) | 1104 (2.57) | 943 (2.18) | 820 (1.88) | 1040 (2.49) |
| Adjusted IMD | 321 (0.80) | 349 (0.87) | 239 (0.59) | 296 (0.72) | 374 (0.90) | 322 (0.77) | 321 (0.76) | 326 (0.76) | 278 (0.64) | 242 (0.55) | 307 (0.74) |
| Adjusted by improved bacterial culture + PCR diagnosisd | |||||||||||
| Additional Nm identified | 234 (0.59) | 255 (0.63) | 188 (0.46) | 207 (0.50) | 206 (0.50) | 226 (0.54) | 166 (0.39) | 185 (0.43) | 215 (0.50) | 170 (0.39) | 205 (0.49) |
| Adjusted NMBM | 937 (2.35) | 1020 (2.53) | 696 (1.71) | 866 (2.11) | 1090 (2.62) | 939 (2.24) | 937 (2.21) | 952 (2.22) | 812 (1.88) | 707 (1.62) | 896 (2.15) |
| Adjusted IMD | 472 (1.18) | 513 (1.27) | 351 (0.86) | 435 (1.06) | 549 (1.32) | 473 (1.13) | 471 (1.11) | 478 (1.12) | 409 (0.95) | 355 (0.81) | 450 (1.08) |
NMBM, non-meningococcal bacterial meningitis; ICD-10, International Classification of Diseases, 10th Revision codes; IMD, invasive meningococcal disease; IR, incidence rate; Nm, Neisseria meningitidis; PCR, polymerase chain reaction; SNVS, National Clinical Surveillance System.
ICD-10 code G00 is the addition of codes G00.0, G00.1, G00.8 and G00.9.
ICD-10 code A39 means cases of meningitis and other invasive forms due to N. meningitidis.
Adjustment by coverage considering that 60.0% of the Argentinian population is covered by the SNVS [22].
Adjustment to account for the diagnostic methods, with a ratio of 1:3.39 (for bacterial culture diagnosis) and 1:1.99 (for bacterial culture + PCR), based on the reported data from Gentile et al. (2017) [20].