Table 1.
lncRNA linked the lipid and inflammation in atherosclerosis.
| lncRNA | Expression | Disease | mRNA | Function | Ref |
|---|---|---|---|---|---|
| DYNLRB2-2 | ↑ | ox-LDL treated THP-1 or Raw264.7 LPS treatment |
miR-298/ SIRT3 /ABCA1 ABCA1/GPR119 TLR2 |
Lipid accumulation (–) Lipid accumulation (–) Inflammation (–) Lipid accumulation (–) Inflammation (–) |
(12) (63) (64) |
| ANRIL | ↓ | High-fat diet ApoE−/− mice ox-LDL-exposed THP-1 High-fat diet ApoE−/− mice LPS-treated HCAECs HUVECs TNF-α-treated ECs |
miR-181a/ SIRT1 ADAM10 CDKN2B miR-181b/ NF-κB NF-κB |
Apoptosis of VSMCs (–) Lipid accumulation (–) Inflammation (–) Lipid accumulation (+) Inflammation (+) Inflammation (+) |
(65) (66) (67, 68) (69) (70) |
| TUG1 | ↑ | High-fat diet ApoE−/− mice ox-LDL-exposed THP-1 ox-LDL treated HCAECs |
miR-133a/ FGF1 miR-26a |
Lipid accumulation (+) Inflammation (+) Apoptosis (+) |
(71) (72) |
| GAS5 | ↑ | ox-LDL treated ECs ox-LDL-treated HAECs, THP-1 cells |
miR-221 /MMP-2 / MMP-9, miR-26a |
Inflammation (+) Inflammation (+) Apoptosis (+) |
(73) (74) |
| CHROME | ↑ | CAD patients | miR-27b and miR-33a/b/ ABCA1, NF-κB |
Inflammation (+) Inflammation (+) |
(75) (76) |
| MALAT1 | ↑ | CAD patients ox-LDL-treated HUVECs |
EndMT PI3K/AKT pathway, miR-216a-5p, miR-15b-5p/mTOR miR-22-3p/CXC 2 miR-155/ SOCS1 /JAK/STAT pathway |
Apoptosis (+) Inflammation (+) Inflammation (–) Inflammation (–) |
(77–80) (81) (82) (83) |
| MEG3 | ↑ | ox-LDL-treated HAECs, THP-1 High fat diet ApoE−/− mice ox-LDL-treated HCAECs ox-LDL-treated HCAECs |
NEAT1 P53 miR-361-5p/ ABCA1 miR-223 /NLRP3 miR-204/CDKN2A |
EC apoptosis (+) Inflammation (+) Pyroptosis (+) Inflammation (+) |
(84) (84) (85) (86) |
| HOTAIR | ↑ | ox-LDL treated Raw264.7 cells ox-LDL-treated ECs ox-LDL treated RAW264.7 |
- FXR1 /NF-κB PI3K/Akt |
Apoptosis (–) Inflammation (–) Inflammation (–) Inflammation (–) |
(82) (83) (84) |
| MIAT | ↑ | ox-LDL-treated THP-1 High-fat diet ApoE−/− mice |
miR-181b/STAT3 | Apoptosis (+) | (87) |
| H19 | ↑ | ox-LDL-treated HCAMCs ox-LDL-treated HUVECs |
miR-148b miR-let-7 |
Apoptosis (+) Apoptosis (+) |
(88) (89) |
| RP5-833A20.1 | ↑ | ox-LDL-treated HCAMCs | miR-382-5p/ NFIA | Lipid accumulation (–) Inflammation (–) |
(90) |
| HOXC-AS1 | ↓ | ox-LDL-treated | ABCA1, ABCG1 HOXC6 |
Lipid accumulation (–) | (91) |
| AC096664.3 | ↓ | ox-LDL-treated Human macrophages |
PPAR-γ/ABCG1 | Lipid accumulation (–) | (92) |
| LncRNA-FA2H-2 | ↓ | ox-LDL-treated THP-1 ox-LDL treated THP-1 |
MLKL/ p38MAPK/PI3K |
Autophagy (+) Inflammation (+) |
(93) |
| DAPK1-IT1 | ↑ | High-fat fed ApoE−/− mice ox-LDL treated ECs or SMCs ApoE−/− mice ox-LDL treated THP-1 |
miR-590-3p/LPL/ ABCA1, ABCG1 CD36/NF-κB |
Lipid accumulation (+) Inflammation (+) |
(94) |
↑, increase; ↓, decrease; +, promote; –, inhibit.