*Itil 1971.

Methods	Allocation: randomly assigned, no further details. Blindness: double. Design: 2 parallel groups, single centre. Duration: 12 weeks. Analysis: not clearly described in the report, (ITT)?* Country: USA.
Participants	Diagnosis: schizophrenia, no further details. N=60. Age: range 16‐46 years, mean 28.2 years. Sex: M 44, F 14*. Setting: hospital. History: acute schizophrenics (length of illness 3 weeks to 35 months.
Interventions	1. Trifluoperazine: range 10‐160 mg/day. N=30. 2. Molindone: range 10‐160 mg/day. N=30.
Outcomes	Leaving the study early. Global state: (discharged from hospital). Side effects: (cataracts, cardiovascular, laboratory abnormalities). Unable to use ‐ EEG: (no usable data). Mental state: (BPRS ‐ no data). Behaviour: (NOSIE ‐ no data). Global state: (ECDU ‐ no data). Side effects ‐ not known how many incidents took place in the same patient.
Notes	* ITT unclear # Demographic characteristics only reported for 58 patients.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear