*Pinard 1972.

Methods	Allocation: randomly assigned (random number table, blocks of 5, matched for treatment symptom severity (BPRS), sex, ward, evaluator). Blindness: double. Design: 5 parallel groups. Duration: 70 days‐preceeded by 21 days where all had chlorpromazine 100 mg/day. Analysis: not clearly described in the report, (ITT?)*. Country: Canada.
Participants	Diagnosis: "schizophrenics", no further details. N=80. Age: range 20‐60 years. Sex: "equally represented". Setting: hospital. History: chronic, hospitalised for the last 2 years, no exacerbation in last year, in hospital for only social or personal reasons.
Interventions	1. Trifluoperazine: dose 5 mg/tds. N=16. 2. Trifluoperazine: dose 15 mg/day. N=16. 3. Pimozide: dose 3 mg/day. N=16. 4. Pimozide: dose 6 mg/day. N=16. 5. Placebo: N=16. Chlorpromazine, methyprylon, benztropine as required.
Outcomes	Leaving the study early. Unable to use ‐ Mental state: (BPRS ‐ 'p' values only). Behavior: (NOSIE ‐ graph only). Side effects: (Extrapyramidal symptom rating BEP ‐ graph only). Insight scale: (Echelle D"Autocritique ‐ no usable data).
Notes	* ITT unclear.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear