*Simpson 1971.

Methods	Allocation: randomly assigned acording to a code prepared in advanced and held by the pharmacist" ‐ no information how the code was prepared. Blindness: double. Duration: 4 weeks (preceeded by 3 days washout). Design: 2 parallel groups, single centre. Analysis: intention to treat performed only for global change in condition, others outcomes were not clearly described*. Country: USA.
Participants	Diagnosis: described elsewhere ‐ Angus 1969. N=52. Age: range 20‐48 years, mean 37.3 years. Sex: M 16, F 36. Setting: hospital. History: acute schizophrenia or acute exacerbation of chronic schizophrenia.
Interventions	1. Trifluoperazine: range 20‐45 mg/day (mean 35mg). N=25. 2. Molindone: range 40‐120 mg/day (mean 75mg). N=27.
Outcomes	Global state: (global rating of change in condition). Side effects. Use of antiparkinson agents. Leaving the study early. Unable to use ‐ Mental state: (BPRS ‐ no SD). Behaviour: (NOSIE ‐ no SD).
Notes	* ITT unclear in some outcomes.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate