*Vestre 1970.

Methods	Allocation: randomised after ranking for withdrawal on Psychotic Reaction Profile, no further details. Blindness: double (raters reported as blind, identical capsules). Design: double cross‐over, single centre. Duration: 2 week placebo washout, 7 weeks on one drug, 2 weeks placebo washout, 7 weeks on second drug. Analysis: intention‐to‐treat not clearly described in the report. Country: USA.
Participants	Diagnosis: schizophrenia, no further details. N=60. Age: range 23‐65 years, mean 43 years. Sex: all male. Setting: hospital. History: chronic illness (mean hospitalisation 15 years).
Interventions	1. Trifluoperazine: range 5‐40 mg/day. N=30. 2. Thioridazine: range 200‐800 mg/day. N=30.
Outcomes	Leaving the study early. Unable to use ‐ Mental state: (BPRS; Psychotic Reaction Profile ‐ only significance tests). Adverse events: (only significance tests).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear