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. 2004 Jan 26;2004(1):CD003545. doi: 10.1002/14651858.CD003545.pub2

Andersen 1974.

Methods Allocation: randomly assigned (described on Andersen 1972 preliminary results), no further details. 
 Blindness: double (commercial preparations but administered by people not involved in the trial). 
 Design: 2 parallel groups. 
 Duration: 3 months. 
 Analysis: intention‐to‐treat not performed in the trial. 
 Country: Sweden.
Participants Diagnosis: schizophrenia or paranoid syndrome.** 
 N=40. 
 Age: range 21‐65 years. 
 Sex: M 19, F19. 
 Setting: hospital. 
 History: chronic patients. 
 Inclusion: hospitalisation < 10 years, no organic disorders, no substance abuse, no depression episodes, no violent patients.
Interventions 1. Trifluoperazine: range 3‐12 mg/bid (mean 4.34 mg). N=20. 
 2. Pimozide: range 3‐14 mg/day (mean 3.92 mg). N=20.
Outcomes Side effects. 
 Use of antiparkinson agents. 
 Leaving the study early.
Unable to use ‐ 
 Mental state: (scale ‐ 'p' values only). 
 Behaviour: (Wing behaviour scale ‐ 'p' values only). 
 Side effects: (point rating scale ‐ validity unknown).
Notes ** Mixed diagnosis.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear