Andersen 1974.
Methods | Allocation: randomly assigned (described on Andersen 1972 preliminary results), no further details. Blindness: double (commercial preparations but administered by people not involved in the trial). Design: 2 parallel groups. Duration: 3 months. Analysis: intention‐to‐treat not performed in the trial. Country: Sweden. | |
Participants | Diagnosis: schizophrenia or paranoid syndrome.** N=40. Age: range 21‐65 years. Sex: M 19, F19. Setting: hospital. History: chronic patients. Inclusion: hospitalisation < 10 years, no organic disorders, no substance abuse, no depression episodes, no violent patients. | |
Interventions | 1. Trifluoperazine: range 3‐12 mg/bid (mean 4.34 mg). N=20. 2. Pimozide: range 3‐14 mg/day (mean 3.92 mg). N=20. | |
Outcomes | Side effects.
Use of antiparkinson agents.
Leaving the study early. Unable to use ‐ Mental state: (scale ‐ 'p' values only). Behaviour: (Wing behaviour scale ‐ 'p' values only). Side effects: (point rating scale ‐ validity unknown). |
|
Notes | ** Mixed diagnosis. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |