Coons 1962.

Methods	Allocation: randomly assigned (by Dr. Coons independently, code in a sealed envelope). Blindness: double (identical capsules, coded bottles). Design: 3 parallel groups, single centre. Duration: 6 weeks (preceded by 8 days washout). Analysis: intention‐to‐treat. Country: Canada.
Participants	Diagnosis: ** mixed (˜79,4% schizophrenia; ˜12% affective psychoses; ˜5% psychoneuroses; ˜3.6% outros, ˜12% leucotomy). N=117. Age: ˜47 years. Sex: female. Setting: hospital. History: long term hospital patients (mean˜141 months).
Interventions	1. Trifluoperazine: dose 15 mg/day. N=39. 2. Chlorpromazine: dose 150 mg/day. N=39. 3. Placebo. N=39.
Outcomes	Use of antiparkinson agents. Unable to use ‐ Behaviour: (Hospital Adjustment Scale ‐ no data).
Notes	** Mixed diagnosis.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate