Denber 1972.

Methods	Allocation: randomly assigned, (random code was unknown until the end of study). Blindness: double (identical capsules dispensed by the research nurse). Design: 2 parallel groups, single centre. Duration: average of 36 days. Analysis: intention‐to‐treat. Country: USA.
Participants	Diagnosis: ** 26 schizophrenics; 1 psychose + mental deficiency and 3 involutional psychoses. N=31 (30 patients, one patient participated twice). Age: no data. Sex: only female. Setting: hospital. History: acute illness.
Interventions	1. Trifluoperazine: dose (mean 58.7 mg/day). N=15. 1. Thiothixene: dose (mean 49 mg/day). N=16.
Outcomes	Side effects: (total number; specific). Global state: (global clinical evaluation). Weight changes. Use of antiparkinson agents. Leaving the study early. Unable to use ‐ Mental state: (IMPS).
Notes	** Mixed diagnosis, one patient participated twice.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate