Edwards 1980.

Methods	Allocation: randomly assigned in advance and held by the hospital pharmacist (open list of random numbers). Blindness: double. Design: 2 parallel groups, single centre. Duration: 6 weeks (preceded by 1 month washout if possible). Analysis: intention‐to‐treat not performed in the trial. Country: UK.
Participants	Diagnosis: schizophrenia, Schneider 1959. N=38. Age: range 25‐74 years, majority 55‐64 years. Sex: M 33, F 5. Setting: hospital. History: long‐stay inpatients, 36 ill >10 years.
Interventions	1. Trifluoperazine: range 15‐45 mg/day (mean 27.7 mg). N=19. 2. Sulpiride: range 600‐1800 mg/day (mean 1212 mg). N=19.
Outcomes	Global state: (change in condition; severity of illness). Leaving the study early. Use of hypnotic. Use of antiparkinson agents. Side effects: (specific list). Unable to use ‐ Mental state: (BPRS ‐ no SD). Side effects: (Simpson and Angus Scale ‐ no SD). Physiological measures: (handwriting, weight, pulse, blood pressure ‐ no SD). Live events ‐ denominator unclear.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate