O'Brien 1974.

Methods	Allocation: randomly assigned (code held by a technician who was not responsible for allocation). Blindness: double (identical capsules, coded bottles). Design: 2 parallel groups, 2 centres. Duration: 3 weeks. Analysis: intention‐to‐treat not performed in the trial. Country: USA.
Participants	Diagnosis: patients with symptoms of hostility, suspiciousness, paranoia and aggressiveness; 20 schizophrenics*. N=30. Age: mean ˜30 years. Sex: M 22, F 2. Setting: hospital.
Interventions	1. Trifluoperazine: dose 9‐48 mg/day. N=15. 2. Haloperidol: dose 3‐20 mg/day. N=15.
Outcomes	Global state. Leaving the study early. Use of antiparkinson agents. Unable to use ‐ Mental state: (BPRS; Global Hostility; Global Paranoia ‐ no SD). Psychological Tests: (Buss‐Durkee hostility inventory; Rozenzweig picture frustration test; MMPI and Rorshach test ‐ no data).
Notes	**Mixed diagnosis.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate