Perales 1974.

Methods	Allocation: randomly assigned by random table (independently and secretly by the head of the project). Blindness: double (treatment and evaluation made by 2 independent psychiatrists blind to drug taken). Design: 2 parallel groups, single centre. Duration: 45 days. Analysis: intention‐to‐treat. Country: Peru.
Participants	Diagnosis: schizophrenia no further details. N=30. Age: range 19‐43 years, mean 31.3 years. Sex: M 26, F 4. Setting: hospital. History: acute state of paranoid schizophrenia.
Interventions	1. Trifluoperazine: dose first 5 days 2‐8 amp (2‐8 mg IM), then 10‐40 mg. N=15. 2. Clotiapine: dose first 5 days 1‐4 amp (40‐160 mg IM), then 40‐60 mg. N=15.
Outcomes	Global state: (clinical evaluation). Side effects. Unable to use ‐ Mental state: (BPRS). Side effects: (Extrapiramidal signs ‐ Bordeau scale). Use of antiparkinson agents.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate