Reardon 1966.

Methods	Allocation: randomly assigned, no further description. Blindness: double. Design: 3 parallel groups, single centre. Duration: minimum 4 weeks, maximum 12 weeks. Analysis: intention‐to‐treat not performed in the trial. Country: USA.
Participants	Diagnosis: paranoid schizophrenia (Bleuler criteria). N=34. Age: not stated. Sex: M 22, F 12. Setting: hospital. History: "acute" illness.
Interventions	1. Trifluoperazine: dose 20 mg/day (week 1), 40 mg/day thereafter. N=11. 2. Chlorpromazine: dose 300 mg/day (week 1) 600 mg/day thereafter. N=11. 3. Placebo: 2‐4 cc/day (week 1), 5‐10 cc/day thereafter. N=12. Artane 10 mg/day prophylactically.
Outcomes	Leaving study early. Global state: (lack of previously observed delusions and hallucinations). Unable to use ‐ Mental state: (MMPI ‐ no SD). Shipley Hartford. WAIS.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear