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. 2005 Oct 19;2005(4):CD003539. doi: 10.1002/14651858.CD003539.pub2

10. Effect of intervention on patient clinical outcome.

Study Patient Outcome Main Process Effect Absolute change Relative change Notes
Little 2001 Otitis media symptom resolution (with and without immediate antibiotic treatment) Comparison: Delayed prescription vs immediate prescription 
 
 Duration of symptoms(mean days) 
 Immediate: 2.56 
 Delayed: 3.57 Absolute difference: ‐1.10 days   Absolute difference of ‐1.10 days, 95% CI ‐0.54 to ‐1.48), p<0.01by t‐test
Arroll 2002 Common cold symptom resolution (with and without immediate antibiotic treatment) Comparison: Delayed prescription vs immediate prescription 
 
 Symptom score at days 3, 7, 10 
 Day 3 
 Immediate: 2.9 
 Delayed: 3.6 
 
 Day 7 
 Immediate: 1.8 
 Delayed: 2.0 
 
 Day 10 
 Immediate: 1.4 
 Delayed: 1.5     General linear model for repeated measures shows no significance for the symptom score (p=0.29)