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. 2005 Oct 19;2005(4):CD003539. doi: 10.1002/14651858.CD003539.pub2

Dolovich 1999.

Methods RCT 
 unit of allocation: region 
 unit of analysis: prescriptions 
 power calculation: not done 
 concealment of allocation: done 
 follow up of professionals: not clear 
 blinded assessment of primary outcomes: done 
 baseline measurement: done 
 reliable primary outcome measure: done 
 protection against contamination: done 
 analysis appropriate: no
Participants 1215 family physicians and pediatricians in 8 regions in Ontario, Canada prescribing antibiotics for children with acute otitis media
Interventions 1. Academic detailing by pharmaceutical detailer + educational materials
2. Routine pharmaceutical detailing
Outcomes Professional practice: 
 Change in market share of recommended first line antibiotic (amoxicillin)
Change in market share of recommended second line antibiotics (pivampicillin, cotrimoxazole and erythromycin‐sulfamethoxazole)
Patient: 
 None
Notes Description of development of the evidence based guideline for management of acute otitis media not provided
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Low risk A ‐ Adequate