MacCara 2001.

Methods	ITS unit of allocation: not applicable unit of analysis: prescriptions protection against secular changes: not clear sufficient data points to enable reliable statistical inference: done formal test for trend: not applicable protection against detection bias: done intervention unlikely to affect data collection: done blinded assessment of primary outcome: done completeness of data set: done reliable primary outcome measure: done analysis appropriate: no
Participants	Physicians of any specialty in Nova Scotia, Canada treating patients over 65 years of age for any community acquired infection
Interventions	1. Financial / health care system change by instituting fluoroquinolone reimbursement guidelines (limitations on prescribing)
Outcomes	Professional practice: Frequency of prescribing fluoroquinolones Frequency of prescribing other antibiotic classes Patient: None
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	D ‐ Not used