Perz 2002.

Methods	CBA unit of allocation: county unit of analysis: episode of care (? account for clustering by having a variable for county in the binomial regression model) power calculation: not done baseline measurement: not done characteristics for studies using second site as control: done blinded assessment of primary outcome: done protection against contamination: done reliable primary outcome measure: done follow up of professionals: not clear analysis appropriate: no (yes?)
Participants	Family practitioners and pediatricians (250 in intervention region, unknown in control regions) in 4 counties in Tennessee, United States treating children under 15 years of age for respiratory tract infection
Interventions	1. Multi‐faceted including educational meetings + printed educational materials for physicians, printed educational materials for parents and patients. 2. No intervention control
Outcomes	Professional practice: Change in rate of prescribing of oral antibiotics Patient: Change in proportion of invasive Streptococcus pneumoniae isolates that are antibiotic resistant
Notes	Campaign message determined by East Tennessee Drug Resistance Task Force and based upon evidence based guidelines: Principles of Judicious Antibiotic Use
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	D ‐ Not used