Seppala 1997.

Methods	ITS unit of allocation: not applicable unit of analysis: prescriptions protection against secular changes: not done sufficient data points to enable reliable statistical inference: done formal test for trend: not done protection against detection bias: done intervention unlikely to affect data collection: done blinded assessment of primary outcome: done completeness of data set: done reliable primary outcome measure: done analysis appropriate: no
Participants	Physicians in Finland treating patients of all ages with respiratory or skin infections
Interventions	1. Printed educational materials (published national guidelines)
Outcomes	Professional practice: Frequency of prescribing macrolide antibiotics Patient: Frequency of isolation of erythromycin resistant Group A streptococci
Notes	Guideline prepared by members of The Finnish Study Group for Antimicrobial resistance
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	D ‐ Not used