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NE binds to α1 adrenergic receptors activating PLC via the Gq protein subunit. PLC either activates (1) PKC, resulting in extracellular Ca2+ entering the cell, or (2) IP3, increasing [Ca2+]i via ER stores. NE also binds to α2 adrenergic receptors in the PVN, but does not participate in the observed [Ca2+]i elevation. The tested mechanistic blockers supporting these results are listed adjacent to their pathway.
