Table 3.

Multivariable Logistic Regression Models of Central Nervous System Metastasis (N = 314 With Complete Information)

Comparison	Excluding Breast Cancer Subtype		Including Breast Cancer Subtype
	OR (95% CI)	P	OR (95% CI)	P
Histology
Ductal vs others	2.01 (1.07‐3.95)	.03	1.78 (0.94‐3.55)	.08
Initial stage
II vs I	1.32 (0.66‐2.73)	.02	1.24 (0.61‐2.58)	.03
III vs I	2.26 (1.08‐4.88)		1.95 (0.91‐4.26)
IV vs I	3.17 (1.37‐7.53)		3.13 (1.34‐7.49)
BRCA status
BRCA1 carrier vs noncarrier	3.05 (1.36‐6.89)	.001a	2.11 (0.89‐4.98)	.005b
BRCA2 carrier vs noncarrier	3.11 (1.43‐6.81)		3.33 (1.51‐7.38)
Breast cancer subtype
TNBC vs others	—		2.24 (1.22‐4.09)	.01

Abbreviations: OR, odds ratio; TNBC, triple‐negative breast cancer.

^aStep‐down Wald tests were used with Bonferonni correction (BRCA1 mutation, corrected P = .01; BRCA2 mutation, corrected P = .008).

^bStep‐down Wald tests were used with Bonferonni correction (BRCA1 mutation, corrected P = .18; BRCA2 mutation, corrected P = .006).