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. 2019 May 14;9(1):21–31. doi: 10.1002/cpdd.695

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© 2019 The Authors. Clinical Pharmacology in Drug Development published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Target attainment for 1500‐mg single‐dose regimen. The projected target MIC attainment for 1500‐mg single‐dose dalbavancin regimen is indicated as a solid line. X axis is logarithmic scale. Histograms represent MIC distributions from 2017 surveillance data for the 4 most relevant species of pathogens. AUC, area under the curve; MIC, minimum inhibitory concentration. Target attainment simulations were run for the 1500‐mg single‐dose regimen using the revised nonclinical pharmacodynamic stasis target of 27.1. Daily average free AUC was calculated as AUC_0‐120/5.