Table 4.
Meta‐analysis for the baseline, end and incremental data evaluating the efficacy of ADS added to CHX‐MW on plaque and gingival inflammation in (a) non‐brushing studies and (b) brushing studies
| Index | Measurement moment | Included studies | Model | DiffM | Test overall | Test for heterogeneity | For details see online Appendix | ||
|---|---|---|---|---|---|---|---|---|---|
| 95% CI | P‐value | I 2 value (%) | P‐value | ||||||
| (a) Non‐brushing | |||||||||
|
SI Lobene (1968)51 |
Base |
Li et al (2013) Marelli et al (2015)a Weinstein & Weinstein (2014) |
Random (SMD) |
−0.39 | [−1.09; 0.31] | 0.27 | 87 | <0.00001 | S3a |
| End |
Basso et al (2008) Li et al (2013) Marelli et al (2015)a Weinstein & Weinstein (2014) |
Random (SMD) |
−3.19 | [−4.98; −1.41] | 0.0005 | 97 | <0.00001 | S3b | |
| Diff |
Basso et al (2008) Li et al (2013) Marelli et al (2015)a Weinstein & Weinstein (2014) |
Random (SMD) |
−3.03 | [−4.76; −1.30] | 0.0006 | 97 | <0.00001 | S3c | |
|
PI Silness and Löe (1964)39 |
Base |
Arweiler et al (2006) Li et al (2013) Weinstein & Weinstein (2014) Marelli et al (2015)a |
Random | 0.01 | [−0.06; 0.08] | 0.84 | 86 | 0.01 | S4a |
| End |
Arweiler et al (2006) Basso et al (2008) Li et al (2013) Weinstein & Weinstein (2014) Marelli et al (2015)a |
Random | 0.10 | [−0.15; 0.34] | 0.45 | 99 | <0.00001 | S4b | |
| Diff |
Arweiler et al (2006) Basso et al (2008) Li et al (2013) Weinstein & Weinstein (2014) Marelli et al (2015)a |
Random | 0.10 | [−0.16; 0.35] | 0.46 | 98 | <0.00001 | S4c | |
|
GI Löe and Silness (1963)40 |
Base |
Li et al (2013) Weinstein & Weinstein (2014) |
Fixed | −0.01 | [−0.04; 0.02] | 0.62 | 0 | 0.90 | S5a |
| End |
Basso et al (2008) Li et al (2013) Weinstein & Weinstein (2014) |
Fixed | 0.04 | [−0.02; 0.11] | 0.15 | 97 | <0.00001 | S5b | |
| Diff |
Basso et al (2008) Li et al (2013) Weinstein & Weinstein (2014) |
Fixed | 0.05 | [−0.00; 0.11] | 0.06 | 98 | <0.00001 | S5c | |
| (b) Brushing | |||||||||
|
SI CIE (1971)52 |
End |
Varoni et al (2017) Graziani et al (2015)a |
Fixed | 0.12 | [−3.32; 3.55] | 0.95 | 0 | 0.76 | S6a |
|
GI Löe and Silness (1963)40 |
Base | Graziani et al (2015)a | Fixed | 0.11 | [−0.28; 0.49] | 0.59 | 0 | 0.61 | S8a |
| End |
Graziani et al (2015)a Solis et al (2010) |
Fixed | 0.00 | [−0.05; 0.06] | 0.87 | 0 | 0.38 | S8b | |
|
PI Silness and Löe (1964)39 |
End |
Bernardi et al (2005) Pereira et al (2017) Solis et al (2010) Varoni et al (2017) |
Random | 0.01 | [−0.01; 0.02] | 0.29 | 26 | 0.26 | S7a |
Two comparisons arriving from this study.