Table 3.
Patient characteristics, ovarian function and fertility outcomes after cryopreserved ovarian tissue autotransplantation
| Patient 1a | Patient 2 | Patient 3 | Patient 4a | Patient 5 | Patient 6 | Patient 7b | |
|---|---|---|---|---|---|---|---|
| Disease | Breast cancer | Breast cancer | Hodgkin lymphoma | Non‐Hodgkin lymphoma | Hodgkin lymphoma | Ewing’s sarcoma | Breast cancer |
| Age at OTC (y) | 26 | 32 | 29 | 32 | 22 | 20 | 28 |
| Age at transplantation (y) |
31 33 |
35 | 39 |
39 40 |
26 | 26 | 38 |
| Transplantation sites |
Ovary Ovary |
Ovary and peritoneal | Ovary |
Ovary Ovary |
Ovary | Ovary | Ovary |
| Transplanted ovarian slices (n) |
11 11 |
4 | 7 |
8 8 |
12 | 6 | 5 |
| Time to restoration of menstrual cycle (mo) |
3.7 |
6.0 | Not restored |
3.4 3.0 |
2.1 | 2.4 | 3.0 |
| Duration of ovarian function (mo) | Ovarian resection (BRCA1) (38.5) | Ongoing (45.0) | — | Ongoing (47.8) | Ongoing (57.3) | Ongoing (3.3) | Ongoing (15) |
| Pregnancy (n) | 1 | 2 | — | — | 2 | — | 1 |
| Fertility techniques | None |
IVF None |
— | — |
IVF None |
— | None |
| Time to first pregnancy (mo) | 24 | 8 | — | — | 23 | — | 6 |
| Pregnancy outcomes | 1 live birth (followed by ovarian resection due to BRCA1) | 2 live births | — | — | 1 missed abortion, 2 live births | — | 1 live birth |
Abbreviation: IVF, in vitro fertilization; OTC, ovarian tissue cryopreservation.
a
These women underwent 2 autotransplantation procedures.
b
Patient recruitment and ovarian cryopreservation were performed in another hospital.