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. 2019 Dec 1;98(1):79–87. doi: 10.1111/imcb.12303

Figure 2.

Figure 2

The differentiation and functionality of γδ T cells in cord blood (CB) and peripheral blood mononuclear cells (PBMCs) from 2‐ and 5‐year‐old children. The frequencies of (a) CD27+ cells among Vδ1+ cells, (b) CD28+ cells among Vδ1+ cells and (c) CD27− CD28− cells among Vδ1+ cells. The frequencies of (d) CD27+ cells among Vδ2+ cells, (e) CD28+ cells among Vδ2+ cells and (f) CD27− CD28− cells among Vδ2+ cells in CB (n = 12) and in PBMCs from 2‐ (n = 28) and 5‐ (n = 16) year‐old children. The frequency of IFNγ+ cells among Vδ2+ cells after 24‐h stimulation with (g) (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl pyrophosphate (HMB‐PP) or (h) CD3:CD28 beads in PBMCs from 2‐year‐old children (n = 13 and n = 6, respectively) and adults (n = 10 and n = 7, respectively). *P < 0.05, **P < 0.01, ***P < 0.001. Data are combined from a minimum of 10 independent experiments. IFN, interferon; US, unstimulated.