Figure 3.

NRF2 activation rescues the reduced glutathione secretion in AD astrocytes. (a) Relative secreted GSH upon basal conditions and inflammatory stimulation shown as fold change to non‐treated isogenic control astrocytes. Healthy control cells secrete more GSH in basal conditions than AD cells and increase GSH secretion upon inflammatory stimulation, whereas AD cells do not. Activation of NRF2 drastically increases GSH secretion both in healthy and AD cells. (b) Relative cellular GSH levels shown as fold change to non‐treated isogenic control astrocytes. A slight increase is seen also in cellular GSH upon lentiviral induction of NRF2. No difference is seen in the cellular GSH levels between AD and control cells. All data are presented as mean ± SEM, n = 3–4 independent experiments with two isogenic pairs. ***p < .001; **p < .01. ns, non‐significant