Figure 4.

NRF2 activation ameliorates the amyloid secretion profile of AD astrocytes. (a) Secreted Aβ_1‐40 levels. (b) Secreted Aβ_1‐42 levels. (c) Aβ_1‐40/Aβ_1‐42 ratio. NRF2 induction specifically reduces the Aβ_1‐42 secretion from AD astrocytes and thus improves the Aβ_1‐40/Aβ_1‐42 ratio while inflammatory stimulation leads to simultaneous reduction of both amyloid species. All data are presented as mean ± SEM, n = 3 independent experiments with two isogenic pairs. ***p < .001; **p < .01; ns, non‐significant